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Electrochemical usage. After initiation of an action potential, the refractory period is defined two ways: The absolute refractory period coincides with nearly the entire duration of the action potential. In neurons, it is caused by the inactivation of the Na+ channels that originally opened to depolarize the membrane.Click to see full answer. Similarly, you may ask, what happens during absolute refractory period?During the absolute refractory period, the neuron cannot be excited to generate a second action potential (no matter how intense the stimulus). This recovery period is the relative refractory period during which a stronger than normal stimulus is needed to initiate a new action potential.Also Know, what is the relative refractory period? Medical Definition of relative refractory period : the period shortly after the firing of a nerve fiber when partial repolarization has occurred and a greater than normal stimulus can stimulate a second response — compare absolute refractory period. Similarly one may ask, what does the refractory period prevent? It is initiated by paced or sensed events; after a sensed event, the refractory period prevents double counting the same event, whereas after a paced event, it prevents sensing the pacing stimulus, its after-potential, or the evoked response. Events within the refractory period do not reset the LRI.Why an action potential Cannot be initiated during the absolute refractory period?Because voltage-gated Na+ channels are inactivated at the peak of the depolarization, they cannot be opened again for a brief time—the absolute refractory period. Because of this, depolarization spreading back toward previously opened channels has no effect.

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